Escherichia coli NISSLE 1917 (EcN) is a Gram-negative strain with many prominent probiotic properties in the treatment of intestinal diseases such as diarrhea and inflammatory bowel disease (IBD), in particular ulcerative colitis. EcN not only exhibits antagonistic effects on a variety of intestinal pathogenic bacteria, but also regulates the secretion of immune factors in vivo and enhances
Specifically, we focus on probiotic E. coli Nissle 1917 and interrogate its effect on persister survival and DNA repair during the post-fluoroquinolone treatment period. Escherchia coli Nissle was isolated from a soldier who remained healthy during a dysentery outbreak in a German field hospital at the height of World War I (Sonnenborn, 2016).
In this study, E.coli Nissle 1917 (EcN), an intestinal probiotic, was utilized as a targeted transport vector to deliver p53 and Tum-5 protein to tumor hypoxic regions. The tumor-targeting characteristics of EcN were investigated using luciferase Lux CDABE operon, and the results demonstrated that EcN could specifically accumulate in the solid
大肠杆菌Nissle 1917 (Escherichia coli Nissle：1917,ECN)是一种益生菌，通常用于治疗某些胃肠道疾病，如高氨血症，以及肠道外的疾病，如癌症检测和治疗。. 由于大肠杆菌生物学知识的丰富和操作的简便性，它正迅速成为开发治疗性工程菌的重要目标。. 通常在应用时常

The probiotic E. coli strain Nissle 1917 (EcN) is the active component of the pharmaceutical preparation Mutaflor® and has been successfully used in the treatment of gastrointestinal disorders. Gut bacteriophages are dominant players in maintaining the microbial homeostasis in the gut, however, their interaction with incoming probiotic

Nissle took a stool sample from the healthy soldier and isolated a strain of Escherichia coli from it (1). This new strain — which scientists later named E. coli Nissle 1917 (EcN) in Nissle's honor — inhibited multiple bacterial pathogens and went on to become one of the best studied bacterial probiotics ever (2). aSnu.
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